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Mutation at codon 249 of p53 gene in a human hepatoblastoma
Author(s) -
Kar Siddhartha,
Jaffe Ron,
Carr Brian I.
Publication year - 1993
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840180314
Subject(s) - transversion , hepatoblastoma , hepatocellular carcinoma , mutation , gene , hepatitis b virus , hepatology , biology , cancer research , genetics , medicine , virology , virus
G‐to‐T transversion at codon 249 of the p53 gene has been shown to be specifically associated with human hepatocellular carcinomas, particularly that subset associated with exposure to the chemical hepatocarcinogen aflatoxin B 1 . We surveyed 47 North American adult hepatocellular carcinomas and three childhood liver tumors for codon 249 mutation. We report here a case of childhood hepatoblastoma in a patient, without known exposure to aflatoxin B 1 or hepatitis B or C virus, whose tumor had a mutation at codon 249 involving G‐to‐T transversion. (HEPATOLOGY 1993;18:566–569.)