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Intercellular immune adhesion molecules in human liver transplants: Overview on expression patterns of leukocyte receptor and ligand molecules
Author(s) -
Steinhoff Gustav,
Behrend Matthias,
Schrader Bettina,
Pichlmayr Rudolf
Publication year - 1993
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840180231
Subject(s) - cell adhesion molecule , extracellular matrix , microbiology and biotechnology , immune system , intercellular adhesion molecule , integrin , cell adhesion , biology , receptor , immunology , soluble cell adhesion molecules , inflammation , intercellular adhesion molecule 1 , cell , biochemistry
Recently it has become clear that the inflammatory response of immune cells to target cells and extracellular matrix is regulated by several receptor‐ligand molecules. Three main classes of molecules mediating intercellular adhesion and activation processes have been identified: the integrin, immunoglobulin and selectin families. This study surveys the expression of adhesion molecules on resident and infiltrating cells in human liver grafts. The patterns of cellular expression and inducibility in different pathological conditions of the graft are described. Our results show organ‐specific regulation of the different adhesion molecules during alloreactive reactions and other types of inflammatory reactions. No rejection‐specific patterns were detected on comparison with reperfusion damage or infectious transplant inflammation. Major differences were noted in the composition of the portal tract and sinusoid with regard to endothelial and parenchymal cell expression of cell‐cell and cell‐matrix adhesion molecules. Intravascular and interstitial differences in the expression patterns of leukocyte adhesion receptors support a concept of stepwise expression. The implications for the appearance of inflammatory reactions in human liver in immunosuppressive and therapeutic interventions are discussed. (H EPATOLOGY 1993;18:440–453).