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Pulmonary hemorrhage and glomerulonephritis in primary biliary cirrhosis
Author(s) -
Bissuel François,
Bizollon Thierry,
Dijoud Frédérique,
Bouletreau Paul,
Cordier Jean François,
Chazot Charles,
Gouillat Christian,
Trepo Christian
Publication year - 1992
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840160609
Subject(s) - primary biliary cirrhosis , medicine , glomerulonephritis , biliary cirrhosis , pulmonary hemorrhage , vasculitis , cirrhosis , gastroenterology , lung , immunology , pathology , antibody , kidney , autoimmune disease , disease
We observed life‐threatening intrapulmonary hemorrhages and focal proliferative glomerulonephritis in a 41‐yr‐old woman with primary biliary cirrhosis. The severity of the symptoms necessitated blood transfusions and mechanical ventilation; the patient improved with the help of corticosteroid therapy. No formal evidence of either Goodpasture's syndrome or any other well‐defined systemic vasculitis could be found. Neutrophil cytoplasmic antibodies were initially positive and became undetectable after 3 mo of immunosuppressive treatment without relapse. This association has not been described previously and may be added to the list of extrahepatic immune‐mediated conditions associated with primary biliary cirrhosis.