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Plasma levels of brain natriuretic peptide in patients with cirrhosis
Author(s) -
La Villa Giorgio,
Romanelli Roberto Giulio,
Raggi Vincenzo Casini,
TostiGuerra Cristina,
De Feo Maria Laura,
Marra Fabio,
Laffi Giacomo,
Geñtilini Paolo
Publication year - 1992
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840160126
Subject(s) - cirrhosis , brain natriuretic peptide , medicine , natriuretic peptide , cardiology , heart failure
Plasma levels of brain natriuretic peptide, a recently identified cardiac hormone with natriuretic activity, were measured in 11 healthy subjects, 13 cirrhotic patients without ascites, 18 nonazotemic cirrhotic patients with ascites and 6 patients with cirrhosis, ascites and functional kidney failure. Plasma levels of brain natriuretic peptide were similar in healthy subjects and cirrhotic patients without ascites (5.56 ± 0.65 and 7.66 ± 0.68 fmol/ml, respectively). In contrast, cirrhotic patients with ascites, with and without functional kidney failure, had significantly higher plasma concentrations of brain natriuretic peptide (19.56 ± 1.37 and 16.00 ± 1.91 fmol/ml, respectively) than did healthy subjects and patients without ascites (p < 0.01); no significant difference was found between the two groups of cirrhotic patients with ascites with respect to this parameter. In the whole group of cirrhotic patients included in the study, brain natriuretic peptide level was directly correlated with the degree of impairment of liver and kidney function, plasma renin activity and plasma levels of aldosterone and atrial natriuretic peptide. The results of this study indicate that brain natriuretic peptide is increased in cirrhotic patients with ascites and suggest that sodium retention in cirrhosis is not due to deficiency of this novel cardiac hormone. (H EPATOLOGY 1992;16:156–161.)