Premium
Time course of hepatitis A virus antibody titer after active and passive immunization
Author(s) -
Fujiyama Shigetoshi,
Iino Shiro,
Odoh Koichi,
Kuzuhara Shoji,
Watanabe Hiroaki,
Tanaka Masahiko,
Mizuno Kyosuke,
Sato Tatsuo
Publication year - 1992
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840150602
Subject(s) - virology , immunization , titer , medicine , antibody , antibody titer , immunology , virus
Abstract To investigate the antibody titer necessary to prevent hepatitis A virus infection, either 15 or 7.5 mg/kg of immune serum globulin was injected into 10 antihepatitis A virus negative volunteers and their serum antihepatitis A virus titers were observed for 28 wk. In addition, antibody titers were observed for 96 wk in a phase 1 clinical trial of a hepatitis A vaccine. The two studies were then compared to assess the immunogenicity of the vaccine and the persistence of the antibody. Serum‐neutralizing antibody titers that were greater than or equal to 4 (considered as positive) persisted for 18 wk and 14 wk after the injection of 15 and 7.5 mg/kg of globulin, respectively. Hepatitis A virus vaccine recipients showed adequate neutralizing antibody titers, with the groups receiving 1, 0.5 and 0.25 μg/dose showing titers of 4 5.5 , 4 4.7 and 4 4 , respectively, at 18 mo after the third inoculation. These findings suggested that effective blood antibody titers were likely to be retained in the 1.0 μg or 0.5 μg/dose groups for at least several years. Moreover, the serum antihepatitis A virus titers demonstrated by a modified radioimmunoassay changed in parallel with the neutralizing antibody titers in the volunteers injected with globulin. (H EPATOLOGY 1992;15:983‐988).