Premium
Hemodynamic effects of terbutaline, a β 2 ‐adrenoceptor agonist, in conscious rats with secondary biliary cirrhosis
Author(s) -
Poo Jorge L.,
Braillon Alain,
Hadengue Antoine,
Gaudin Christophe,
Lebrec Didier
Publication year - 1992
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840150318
Subject(s) - terbutaline , medicine , portal venous pressure , hemodynamics , portal hypertension , hyperdynamic circulation , vascular resistance , endocrinology , cirrhosis , splanchnic , agonist , cardiac output , blood pressure , receptor , asthma
The hemodynamic responses to terbutaline – a selective β 2 ‐adrenoceptor agonist – were studied in conscious normal rats and in conscious rats with secondary biliary cirrhosis. Compared with those of normal rats, dose‐response curves in cirrhotic rats indicated significantly decreased reactivity in arterial pressure and heart rate. Half‐maximal effective dose was not significantly different between the two groups. Terbutaline induced significant, dose‐dependent decreases in portal pressure in both normal rats (9.3%) and cirrhotic rats (13.8%). In normal rats, terbutaline administration (32 μg ± min −1 ± kg −1 body wt) increased both cardiac output and portal tributary blood flow, thus mimicking hemodynamic changes in cirrhotic rats. In cirrhotic rats, despite a significant increase in portal tributary blood flow (from 19.9 ± 1.7 ml/min to 22.7 ± 1.5 ml/min), terbutaline decreased portal pressure from 17.4 ± 1.0 mm Hg to 15.0 ± 0.8 mm Hg. This study indicates that increased β 2 ‐adrenoceptor stimulation in cirrhotic rats may be involved in hyperdynamic circulation. The association of a decreased portal pressure and increased splanchnic blood flow suggests that β 2 ‐adrenoceptor stimulation may modulate hepatic and portal collateral vascular resistance. (Hepatology 1992;15:459–463).