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Hepatocyte growth factor receptor and the c‐ Met oncogene
Author(s) -
Fausto Nelson
Publication year - 1991
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840140428
Subject(s) - c met , hepatocyte growth factor receptor , hepatocyte growth factor , cancer research , receptor , hepatocyte , oncogene , medicine , biology , chemistry , cancer , genetics , cell cycle , in vitro
Hepatocyte growth factor (HGF) is a plasminogen‐like protein thought to be a humoral mediator of liver regeneration. A 145‐kilodalton tyrosyl phosphoprotein observed in rapid response to HGF treatment of intact target cells was identified by immunoblot analysis as the β subunit of the c‐ met proto‐oncogene product, a membrane‐spanning tyrosine kinase. Covalent cross‐linking of 125 I‐labeled ligand to cellular proteins of appropriate size that were recognized by antibodies to c‐ met directly established the c‐ met product as the cell‐surface receptor for HGF.