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Hepatorenal reflex regulating kidney function
Author(s) -
Lang Florian,
Tschernko Edda,
Schulze Eva,
Öttl Irina,
Ritter Markus,
Völkl Harald,
Hallbrucker Christian,
Häussinger Dieter
Publication year - 1991
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840140403
Subject(s) - renal function , medicine , endocrinology , glutamine , kidney , hepatorenal syndrome , glucagon , denervation , renal blood flow , urinary system , renal vein , jugular vein , mesenteric vein , chemistry , portal vein , cirrhosis , biochemistry , insulin , amino acid
In anesthetized male rats, infusion of glutamine (2 μmol/min) into the superior mesenteric vein at a rate known to induce liver cell swelling leads to marked decreases in renal glomerular filtration rate, renal para‐aminohippurate clearance and urinary flow rate. Glutamine infused at identical rates into the jugular vein does not elicit any of these effects. The effect of glutamine is mimicked by serine but not by glutamate. Spinal transection, renal denervation or section of the vagal hepatic nerves abolishes the effect of mesenteric venous glutamine infusion. Mesenteric application of glucagon (1 ng/min) or of both glutamine and glucagon enhances glomerular filtration rate and urinary flow rate. Infusion of 1 ng/min glucagon through the jugular vein does not significantly alter glomerular filtration rate or urinary flow rate. The data disclose a powerful liver‐borne mechanism regulating kidney function that is mediated by the hepatorenal innervation. (H EPATOLOGY 1991;14:590–594.)