Premium
Light‐ and electron‐microscopical study of a case of gold salt—induced hepatotoxicity
Author(s) -
Fleischner Gerald M.,
Morecki Rachel,
Hanaichi Takamasa,
Hayashi Hisao,
Quintaelson,
Sternlieb Irmin
Publication year - 1991
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840140304
Subject(s) - gold sodium thiomalate , rheumatoid arthritis , parenchyma , pathology , gold standard (test) , jaundice , medicine , electron microscope , biopsy , physics , optics
A 56‐yr‐old woman with long‐standing rheumatoid arthritis exhibited jaundice, pruritus and abdominal discomfort after 8 yr of periodic gold sodium thiomalate injections amounting to a cumulative dose in excess of 2.5 gm. Histopathological examination of the liver biopsy specimen showed submassive loss of parenchyma, collapse of reticulin and mixed cellular inflammatory infiltrates. Macrophages contained dark granules, which displayed the characteristics of aurosomes when examined by transmission electron microscopy and electron microprobe analysis. It is likely that hepatocellular injury occurred when the lysosomal storage capacity for gold was exceeded.