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Studies on mechanisms of augmentation of liver regeneration by cyclosporine and FK 506
Author(s) -
Francavilla Antonio,
Starzl Thomas E.,
Barone Michele,
Zeng QiHua,
Porter Kendrick A.,
Zeevi Adrianni,
Markus Peter M.,
van den Brink Marcell R. M.,
Todo Satoru
Publication year - 1991
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840140123
Subject(s) - hepatocyte , liver regeneration , hepatocyte growth factor , regeneration (biology) , medicine , endocrinology , cytotoxicity , natural killer cell , immune system , nude mouse , growth factor , biology , pharmacology , immunology , in vitro , receptor , microbiology and biotechnology , cancer , biochemistry
Evidence could not be found of immune modulation of liver regeneration. The powerful immunosuppressive drug FK 506, which augments the response after partial hepatectomy in normal rats, had the same effect in T cell—deficient nude rats. The cytotoxicity of natural killer cells in treated nude rats was not significantly changed by FK 506 therapy. However, the serum of FK 506—treated nude rats increased hepatocyte proliferation when added to third‐party hepatocyte cultures, suggesting that FK 506 had induced a serum growth factor in the nude rats or had suppressed an inhibitory factor. A hypothesis was advanced that FK 506 (and cyclosporine) affects hepatic growth by nonimmunological pathways. (HEPATOLOGY 1991;14:140–143.)