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Sex hormones in postmenopausal women with primary biliary cirrhosis
Author(s) -
Becker Ulrik,
Almdal Thomas,
Christensen Erik,
Gluud Christian,
Farholt Stense,
Bennett Paul,
Svenstrup Birgit,
Hardt Finn
Publication year - 1991
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840130511
Subject(s) - estrone , medicine , primary biliary cirrhosis , sex hormone binding globulin , endocrinology , dehydroepiandrosterone sulfate , androstenedione , estrone sulfate , testosterone (patch) , hormone , cirrhosis , globulin , hepatology , androgen
To evaluate serum sex hormone profiles in nonalcoholic postmenopausal women with liver disease, 25 women with primary biliary cirrhosis (11 in cirrhotic stage) and 46 healthy controls were studied. The patients had significantly (p <0.05) elevated serum concentrations of estrone and androstenedione and significantly (p <0.05) lower concentrations of estrone sulfate, dehydroepiandrosterone sulfate and 5α‐dihydrotestosterone compared with the 46 controls. Serum concentrations of sex hormone binding globulin, testosterone, non‐sex hormone binding globulin‐bound testosterone and non‐protein‐bound testosterone did not differ significantly (p> 0.05) between primary biliary cirrhosis patients and controls. Patients in the cirrhotic stage had significantly (p < 0.05) higher concentrations of sex hormone binding globulin than did controls. Patients in the cirrhotic stage had significantly (p < 0.05) higher sex hormone binding globulin and estrone sulfate levels compared with noncirrhotic patients with primary biliary cirrhosis. Otherwise, no significant differences were observed between cirrhotic and noncirrhotic patients. The observed changes in steroid concentrations may be a consequence of hepatic dysfunction. (H EPATOLOGY 1991;13:865–869.)