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Hyperdynamic circulation in a chronic murine schistosomiasis model of portal hypertension
Author(s) -
Sarin Shiv K.,
Mosca Piergiorgio,
Sabbà Carlo,
Groszmann Roberto J.
Publication year - 1991
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840130329
Subject(s) - schistosomiasis , portal hypertension , hyperdynamic circulation , splanchnic , medicine , hepatology , vascular resistance , portal venous pressure , hemodynamics , gastroenterology , splanchnic circulation , cardiac output , circulatory system , cardiology , cirrhosis , immunology , helminths
Abstract Chronic murine schistosomiasis is a natural disease model of portal hypertension closely mimicking the clinical and histological features of human hepatic schistosomiasis. We studied the splanchnic and systemic hemodynamics in the murine model of schistosomiasis by radioactive microsphere technique. Mice infected with 60 cercariae of Schistosoma mansoni (n = 8) were studied hemodynamically 11 wk after the infection and were compared with age‐matched healthy controls (n = 11). Mean portal venous inflow in the infected mice (3.82 ± 0.32 ml/min) was 61% higher than in the healthy animals (2.37 ± 0.25 ml/min; p < 0.01). A twofold increase in hepatic arterial flow was also seen in mice with schistosomiasis (0.47 ± 0.14 ml/min) as compared with controls (0.16 ± 0.03 ml/min; p < 0.05), whereas splanchnic arteriolar resistance (60.91 ± 7.64 vs. 101.21 ± 11.06 mm Hg · min · ml −1 . gm; p < 0.05) and peripheral vascular resistance (112.05 ± 14.05 vs 254.53 ± 29.86 mm Hg · min ml −1 · gm; p < 0.01) were reduced. There was a significant increase in cardiac index (752 ± 99 vs. 453 ± 55 ml · min −1 · kg body weight −1 ; p < 0.05) and reduction in mean arterial pressure (81.37 ± 3.09 vs. 101.45 ± 5.85 mm Hg; p < 0.05) in the infected animals compared with controls. These observations clearly demonstrate the existence of a hyperdynamic circulatory state in this model of portal hypertension. (H EPATOLOGY 1991;13:581–584.)