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Cytokeratins for probing cell lineage relationships in developing liver
Author(s) -
Desmet V. J.,
van Eyken Peter,
Sciot Raf
Publication year - 1990
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840120530
Subject(s) - cytokeratin , immunohistochemistry , monoclonal antibody , biology , pathology , bile duct , organogenesis , lineage (genetic) , antibody , medicine , immunology , biochemistry , gene
Immunohistochemistry with monoclonal anti‐cytokeratin antibodies has revealed the presence of cytokeratin 19 in embryonic and early fetal hepatocytes. With the differentiation of bile ducts at about the 10th week, cytokeratin 19 disappears from liver cells but remains in bile duct cells. This marks an important step in the organogenesis of the liver.