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31 Phosphorus nuclear magnetic resonance spectroscopy: What does it tell us about alcohol‐induced liver disease?
Author(s) -
Willson R. A.
Publication year - 1990
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840120528
Subject(s) - nuclear magnetic resonance , nuclear magnetic resonance spectroscopy , alcohol , spectroscopy , liver disease , magnetic resonance imaging , medicine , chemistry , physics , radiology , biochemistry , quantum mechanics
1. Patients with a history of alcohol abuse were studied by 31 P n.m.r. spectroscopy of the liver in vivo , and the results were related to the pattern of disease assessed by standard biochemical and histological techniques. 2. The ratios of metabolites measured from the 31 P n.m.r. spectra were abnormal in patients with alcoholic hepatitis but not in those with fatty change or cirrhosis in the absence of hepatitis. In particular, the levels of phosphomonoesters were raised, with respect either to P v , or to adenosine 5′‐triphosphate. The level of phosphomonoesters showed a significant positive correlation with the severity of alcoholic hepatitis, assessed by histology. 3. The ratio of P i to adenosine 5′‐triphosphate was used as a measure of the energy status of the hepatocytes, and was unchanged between patients and controls.