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Effect of chronic administration of ursodeoxycholic acid on the ileal absorption of endogenous bile acids in man
Author(s) -
Marteau Philippe,
Chazouiléres Olivier,
Myara Anne,
Jian Raymond,
Rambaud JeanClaude,
Poupon Raoul
Publication year - 1990
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840120521
Subject(s) - ursodeoxycholic acid , bile acid , placebo , medicine , endogeny , absorption (acoustics) , endocrinology , chemistry , gastroenterology , pharmacology , physics , alternative medicine , pathology , acoustics
The effect of long‐term administration of ursodeoxycholic acid on the ileal absorption of endogenous bile acids was determined using the tauro 23 ( 75 Se) selena‐25 homotaurocholic acid test in a controlled double‐blind study involving healthy subjects (n = 15). Subjects received placebo or 13 to 15 mg/kg/day ursodeoxycholic acid for 5 wk. In the placebo group (n = 7) there was no change in the composition of serum bile acids or in the mean percentage of retention of tauro 23( 75 Se) selena‐25 homotaurocholic acid (36.1% ± 6.0% vs. 38.7% ± 6.7%). In contrast, in the ursodeoxycholic acid group, serum ursodeoxycholic acid conjugates increased and the percentage of retention of tauro 23 ( 75 Se) selena‐25 homotaurocholic acid fell from 45.8% ± 6.8% to 20.5% ± 5.7% (p < 0.01). We conclude that ursodeoxycholic acid administration reduces ileal absorption of endogenous bile acids. These findings provide a rational explanation for the changes in the composition of the bile acid pool during ursodeoxycholic acid therapy and could have important therapeutic implications. (HEPATOLOGY 1990;12:1206–1208).