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Benign recurrent intrahepatic cholestasis: Failure of S‐adenosylmethionine therapy
Author(s) -
Conn Harold O.,
Ghent C. N.
Publication year - 1990
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840120227
Subject(s) - cholestasis , chenodeoxycholic acid , cholic acid , medicine , gastroenterology , bile acid , progressive familial intrahepatic cholestasis , transaminase , liver function tests , endocrinology , chemistry , biochemistry , liver transplantation , enzyme , transplantation
S ‐Adenosylmethionine (800 mg i.v. per day) was used to treat two brothers and a brother and sister from each of two kindreds with benign recurrent intrahepatic cholestasis. Symptoms, routine tests of liver function, concentrations of total bile acids, and the oral clearances of [11,12‐ 2 H]chenodeoxycholic acid and [24‐ 13 C]cholic acid were determined before and after treatment with S ‐adenosylmethionine. S ‐Adenosylmethionine did not ameliorate symptoms or biochemical parameters of cholestasis but reduced bile acid clearances in 3 of 4 subjects. Transaminase levels in both subjects of one kindred rose during treatment. These limited, preliminary observations suggest that S ‐adenosylmethionine may be ineffective in the therapy of benign recurrent intrahepatic cholestasis and may be hepatotoxic in some patients.