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Propranolol‐induced reduction in recurrent variceal hemorrhage in schistosomiasis
Author(s) -
Conn Harold O.
Publication year - 1990
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840110632
Subject(s) - schistosomiasis , propranolol , medicine , reduction (mathematics) , gastroenterology , immunology , helminths , geometry , mathematics
Fifty patients with non‐cirrhotic portal fibrosis who were admitted to hospital because of upper gastrointestinal bleeding were randomly assigned to treatment with either oral propranolol given in does that reduced the resting pulse rate by 25% (25 patients) or with a placebo (25 patients). One year after the start of the study 20 patients in the propranolol group and five patients in the placebo group were free from recurrent gastrointestinal bleeding (p < 0.0001). Giving continuous oral propranolol treatment is therefore effective in preventing recurrent upper gastriontestinal bledding in patients with noncirrhotic portal fibrosis.