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Inhibition of HBV replication during coinfection with HBV and HDV: Inhibition of the inhibition by coinfection with HIV
Author(s) -
Govindarajan Sugantha
Publication year - 1990
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840110427
Subject(s) - coinfection , virology , human immunodeficiency virus (hiv) , replication (statistics) , hepatitis b virus , medicine , virus
Abstract The clinical course, changes in liver function tests and the behaviour of viral markers over the course of time have been examined in 45 patients with acute hepatitis B and 14 patients with acute hepatitis caused by B and D viruses coinfection. There were no significant differences, either in the clinical course or in the liver function tests, in the two groups. The changes in serum viral markers were as follows: HBV‐DNA was the first marker to disappear; this was closely followed by HBeAg, and HBsAg was the last marker to become negative, during convalescence. This pattern was not altered by Delta coinfection. When we quentified serum HBV‐DNA in both groups of patients, we found that Delta virus infection led to partial inhibition of HBV replication, so that serum HBV‐DNA levels were significantly lower in those patients with acute hepatitis B who were simultaneously infected with Delta virus.