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Defenestration of hepatic sinusoids in the pathogenesis of alcoholic hyperlipoproteinemia
Author(s) -
Scheig Robert
Publication year - 1990
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840110128
Subject(s) - chylomicron , endothelium , pathogenesis , medicine , chemistry , endocrinology , lipid metabolism , cholesterol , lipoprotein , very low density lipoprotein
The hepatic sinusoidal endothelium separates sinusoidal blood from hepatocytes; changes in the porosity of this endothelium may affect the passage of chylomicrons into hepatocytes and influence lipid metabolism. Chronic exposure to ethanol reduces the porosity of the endothelium; this mechanism may underlie the hyperlipoprotelium; hyperlipoproteinaemia observed in some people who drink heavily.