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Elevation of facilitated glucose‐transporter messenger RNA in human hepatocellular carcinoma
Author(s) -
Su TsungSheng,
Tsai TingFen,
Chi ChinWen,
Han ShouHwa,
Chou ChenKung
Publication year - 1990
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840110120
Subject(s) - hepatocellular carcinoma , transporter , messenger rna , biology , glucose transporter , gene expression , rna , fetus , liver cell , cell culture , gene , cell , microbiology and biotechnology , endocrinology , medicine , cancer research , biochemistry , genetics , pregnancy , insulin
Complementary DNA of a rat brain glucose transporter gene was used to examine the expression of glucose‐transporter messenger RNA in paired human hepatocellular carcinomas and adjacent nontumorous liver tissues, as well as in human hepatoma cell lines and human fetal liver samples. High expression of a major 2.8‐kilobase glucose‐transporter transcript was seen in all hepatoma cell lines and fetal liver samples examined, whereas a much lower level of expression was observed in liver tissues. When pairs of liver tissues were examined, elevation of glucose‐transporter RNA levels was observed in most of the hepatocellular carcinoma tissues examined.