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Reduction of intrapulmonary shunt and resolution of digital clubbing associated with primary biliary cirrhosis after liver transplantation
Author(s) -
Stoller James K.,
Moodie Douglas,
Schiavone William A.,
Vogt David,
Broughan Thomas,
Winkelman Eugene,
Rehm Patrice K.,
Carey William D.
Publication year - 1990
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840110111
Subject(s) - medicine , primary biliary cirrhosis , liver transplantation , cirrhosis , indocyanine green , shunt (medical) , biliary cirrhosis , chronic liver disease , transplantation , perfusion , pathology , disease , autoimmune disease
This report describes a patient with marked hypoxemia caused by intrapulmonary shunt associated with primary biliary cirrhosis. Liver transplantation resulted in resolution of digital clubbing and reduction of intrapulmonary shunt as demonstrated by normalization of room air arterial blood gases, reduction in shunt fraction and normalization of the indocyanin‐enhanced echocardiogram and perfusion lung scan. This patient's course challenges the conventional notion that intrapulmonary shunting associated with chronic liver disease does not reverse after liver transplantation. (HEPATOLOGY 1990; 11: 54–58.)