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Drug‐binding proteins after liver transplantation: Are they significant?
Author(s) -
Tredger J. Michael,
Williams Roger
Publication year - 1989
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840100326
Subject(s) - liver transplantation , drug , medicine , transplantation , pharmacology , intensive care medicine
In patients with liver disease, the synthesis of drug‐binding proteins may be impaired. After liver transplantation, levels of drug‐binding proteins are unknown. Consequently, concentrations of albumin and α‐acid glycoprotein (AAG) were measured in stable patients after liver transplantation. Albumin levels were decreased from normal (4.5 ± 3 gm per dl) in patients with liver disease before (3.4 ± 0.7) and after transplantation (3.4 ± 0.8). AAG levels were decreased from normal (67 ± 20 mg per dl) in patients with liver disease (46 ± 22) but were higher than normal after transplantation (121 ± 28). AAG is an acutephase reactant, the synthesis of which may have been stimulated by the surgical procedure. The effect of these changes on drug metabolism was not studied.