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Lack of immune potentiation by complexing HBsAg in a heat‐inactivated hepatitis B Vaccine with antibody in hepatitis B immunoglobulin
Author(s) -
Lelie P. Nico,
van Amelsfoort Peter J. A. J.,
Martine de Groot C. S.,
Bakker Ed,
Schaasberg Wim,
Niessen Jos C. M.,
Reesink Henk W.
Publication year - 1989
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840100109
Subject(s) - hbsag , antibody , virology , medicine , immunology , hepatitis b , hepatitis b vaccine , immune system , immunoglobulin g , hepatitis b virus , virus
Abstract In a randomized, dose‐response study among 305 health care workers, we examined whether the immunogenicity of a heat‐inactivated hepatitis B vaccine could be enhanced when HBsAg was complexed by anti‐HBs contained in hepatitis B immunoglobulin either at equivalent proportions or at 10‐fold antigen excess. The dose of HBsAg in the control vaccine as well as in the two complexed vaccine preparations could be reduced from the standard value (3 μg) to 0.6 μg per injection without affecting the antibody response in the vaccinees. Still lower dosages of HBsAg in the three vaccine preparations induced significantly lower but comparable anti‐HBs responses. These results indicate that, in man, using a heat‐inactivated plasma vaccine, addition of anti‐HBs contained in hepatitis B immunoglobulin does not potentiate the immunogenicity of HBsAg.