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Alteration of hepatic tissue spaces by platelet‐activating factor and phenylephrine
Author(s) -
Lapointe David S.,
Olson Merle S.
Publication year - 1989
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840090220
Subject(s) - phenylephrine , extracellular , chemistry , intracellular , platelet activating factor , endocrinology , agonist , medicine , biochemistry , receptor , blood pressure
Mean transit times for the movement of extracellular and intracellular reference compounds through isolated perfused rat livers were determined during exposure of livers to platelet‐activating factor (AGEPC; 1‐0‐hexa‐decyl‐2‐acetyl‐sn‐glycero‐3‐phosphocholine) and the α‐adrenergic agonist phenylephrine, using the multiple indicator dilution technique. From the outflow profiles of rapid bolus injections of 3 H‐sucrose and 14 C‐urea given to the liver, the estimated intracellular volume of distribution of small freely permeant substances, V i , and Θ′, the ratio of intracellular to extracellular space, were computed. Exposure of the liver to AGEPC decreased V i and Θ′ by 32 and 34%, respectively, from control values, whereas infusion of phenylephrine increased V i by 16% and Θ′ by 33%. The results indicate that the hemodynamic effects of AGEPC in perfused rat liver cause the apparent loss of tissue space accessible to small permeant compounds. Phenylephrine, although increasing hepatic vascular resistance, measured at the portal vein, by the same magnitude as AGEPC, led to an increase in the apparent tissue space accessible to this same species.