Premium
Floxuridine‐induced sclerosing cholangitis: An ischemic cholangiopathy?
Author(s) -
Ludwig Jurgen,
Kim Chung H.,
Wiesner Russell H.,
Krom Ruud A. F.
Publication year - 1989
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840090209
Subject(s) - floxuridine , medicine , liver transplantation , transplantation , gastroenterology , metastasis , colorectal cancer , adenocarcinoma , surgery , chemotherapy , cancer , fluorouracil
A 43‐year‐old man underwent abdominoperineal resection of a rectal adenocarcinoma, and left hepatic lobectomy for a single metastasis. He then received hepatic artery infusions of floxuridine. The tumor did not recur, but sclerosing cholangitis and liver failure developed which necessitated orthotopic liver transplantation. In the hilus of the native liver, obstructive arteriopathy and portal venopathy were found. These lesions probably had been caused by drug‐induced intravascular thrombosis. Thus, the sclerosing cholangitis that develops in many patients after floxuridine infusion may be ischemic rather than toxic. The patient described here is well, 14 months after orthotopic liver transplantation. Therefore, in some cases of floxuridine‐induced cholangitis, liver transplantation appears to be indicated despite a history of metastasizing carcinoma.