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Hepatocyte heterogeneity: The coming of age from the description of a biological curiosity to a partial understanding of its physiological meaning and regulation
Author(s) -
Gumucio Jorge J.
Publication year - 1989
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840090124
Subject(s) - meaning (existential) , curiosity , administration (probate law) , citation , center (category theory) , library science , medicine , psychology , gerontology , political science , law , computer science , social psychology , psychotherapist , chemistry , crystallography
the structural unit into three functional zones was proposed. These were called zones 1, 2 and 3 by Rappaport and are equivalent to the periportal, intermediate and perivenous regions only if the landmark used as reference is a terminal portal venule (3). The general consensus was that the main factor regulating these functional differences was the perfusion of these zones with blood of varying composition. To this extent, hepatocyte heterogeneity was seen as an adaptation to a changing sinusoidal microenvironment, a concept which is still prevalent, although not adequately tested.