Premium
Proline‐incorporating cells in chronic active liver diseases
Author(s) -
Hassan Giorgio,
Stefanini Stefania,
Bargagli Anna Maria,
Autuori Francesco
Publication year - 1989
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840090107
Subject(s) - lobules of liver , pathology , proline , immunohistochemistry , antibody , liver biopsy , biopsy , biology , chemistry , medicine , immunology , biochemistry , amino acid
The incorporation of 3 H‐proline in cells of liver biopsy specimens from patients with chronic active liver diseases has been studied by light and electron microscopic autoradiography. The labeled proline is incorporated by hepatocytes of the external rows of the residual liver lobule, by the cells of the proliferating bile ductule and very actively by the plasma cells localized at the boundary between the inflammatory infiltrate and the liver lobule. These plasma cells, which are often in close contact with the hepatocytes at the edge of the liver lobule, appear to be either negative or positive after the immunohistochemical tests for the k and λ chains of immunoglobulins. Results are discussed in relation to both the synthesis of collagen and the role of the immunocompetent cells during the process of the piecemeal necrosis.