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The gold standard serologic marker for hepatitis B virus infectivity
Author(s) -
Seeff Leonard B.
Publication year - 1988
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840080640
Subject(s) - hepatitis b virus , hbeag , infectivity , virology , hepatitis b , hbsag , asymptomatic carrier , virus , medicine , hepatitis , serology , hepadnaviridae , sexual transmission , antibody , immunology , asymptomatic , microbicide , human immunodeficiency virus (hiv)
The authors tested, by molecular hybridization, for hepatitis B virus DNA in serum specimens of 182 asymptomatic hepatitis B surface antigen (HBsAg) Greek carriers who were heterosexual partners of patients with acute hepatitis B (group A: 96 cases) or healthy subjects who were susceptible to hepatitis B (group B: 86 cases). The mean age (34.1 ± 10.4 vs. 33.9 ± 8.4 years) and the mean duration of sexual contact (6.9 ± 8.9 vs. 7.2 ± 6.3 years) were similar in the two groups of carriers. Hepatitis B virus DNA was detected significantly more frequently in group A than in group B (59.4% vs. 11.6%, p < 0.001). In particular, in group A, hepatitis B virus DNA was detected in 96.9% of hepatitis B e antigen (HBeAg)‐positive and 41% of antibody to HBeAg (anti‐HBe)‐positive carriers. In contrast, in group B, hepatitis B virus DNA was identified in only 10.8% of anti‐HBe‐positive carriers ( p < 0.001). These differences were especially significant in the young and middle‐aged carriers (16–49 years old) and during the first four years of sexual contact. These data suggest that 1) there is a positive correlation between the presence of hepatitis B virus DNA in serum and the epidemiologic evidence of sexual transmission of hepatitis B virus, 2) hepatitis B virus DNA is a better indicator of infectivity than HBeAg/anti‐HBe, and 3) the detection of hepatitis B virus DNA in serum probably identified carriers with high infectivity and potentially higher risk of transmitting hepatitis B virus to their sexual partners.