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Dual color fluorescence analysis of peripheral T cell subsets in hepatitis B virus‐induced liver disease
Author(s) -
Hasegawa Kiyoshi,
Yamauchi Katsumi,
Furukawa Takaji,
Obata Hiroshi
Publication year - 1988
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840080528
Subject(s) - fulminant , fulminant hepatitis , medicine , hepatitis , hepatology , fulminant hepatic failure , virus , liver disease , acute hepatitis , virology , immunology , gastroenterology , pathology , liver transplantation , transplantation
By using dual color fluorescence analysis, peripheral T cells can be divided into four different subsets, Leu‐2a + , Leu‐2a + 15 − , Leu‐3a + 8 + and Leu‐3a + 8 − cells. The ratio of these T cell subsets in hepatitis B virus‐induced hepatitis patients was studied and compared with that of controls. No significant difference was found in acute hepatitis and chronic hepatitis, but an elevation of Leu‐2a + 15 − (29.5 ± 2.8% vs. 18.8 ± 4.1%, p < 0.05) as well as a reduction of Leu‐2a + 15 + cells (3.2 ± 0.7% vs. 10.4 ± 3.2%, p < 0.05) were found in fulminant hepatitis patients. In addition, serial studies of two fulminant hepatitis patients revealed that the imbalance of these two Leu‐2a cells was only found in the acute phase, but not in the recovery phase. These results indicate that the imbalance of these two Leu‐2a cells is associated with the clinical status of patients with fulminant hepatitis.