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Influence of male hormones on rates of ethanol elimination in man
Author(s) -
Mezey Esteban,
Oesterling Joseph E.,
Potter James J.
Publication year - 1988
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840080406
Subject(s) - ethanol , orchiectomy , testosterone (patch) , medicine , hormone , endocrinology , alcohol , chemistry , alcohol dehydrogenase , sex hormone binding globulin , body weight , androgen , biochemistry
The effect of a reduction in androgens on ethanol elimination was determined in man. Bilateral therapeutic orchiectomy in nine patients for prostatic carcinoma decreased mean plasma testosterone levels from 489.8 ± 31.2 (S.E.) ng per dl to 55.3 ± 3.8 ng per dl and resulted in an increase in the rate of ethanol elimination in seven patients, no change in one, and a decrease in one. The mean rate of ethanol elimination for all nine patients increased from 83.6 ± 4.0 to 100.4 ± 4.2 mg per kg body weight per hr (p < 0.02). The most likely mechanism for an increase in ethanol elimination after orchiectomy is an increase in liver alcohol dehydrogenase content, which remains to be demonstrated in man.