Premium
Postprandial hemodynamic responses in patients with cirrhosis
Author(s) -
Lee Samuel S.,
Hadengue Antoine,
Moreau Richard,
Sayegh Raymond,
Hillon Patrick,
Lebrec Didier
Publication year - 1988
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840080335
Subject(s) - postprandial , medicine , splanchnic , cirrhosis , hemodynamics , splanchnic circulation , portal venous pressure , cardiology , blood flow , circulatory system , blood pressure , haemodynamic response , gastroenterology , cardiac output , heart rate , portal hypertension , insulin
The hemodynamic response to a 800 kcal liquid meal was investigated in 24 patients (study group) with cirrhosis and two control groups. One control group of six cirrhotic patients (volume control) had a calorie‐free equivolumic electrolyte solution. The second control group (normal control) of six patients with normal hepatic function had the same test meal. Cardiac index, mean arterial pressure, heart rate, hepatic venous pressures, hepatic blood flow and azygos blood flow (only measured in the study group) were measured before and 30 and 60 min after the meal. Systemic circulatory responses were generally absent. Hepatic blood flow and wedged hepatic venous pressure increased significantly in both cirrhotic patients and normal controls; however, cirrhotic patients tended to have a quicker response (peaks at 30 min) than normals (peaks at 60 min). Azygos blood flow showed large postprandial variability, but overall did not change significantly. These results demonstrate that the splanchnic circulation of the patient with cirrhosis reacts differently from normals to the physiologic stimulus of a meal, and in particular appears to have precocious vasoactive reactivity.