Premium
Selenium deficiency in search of a disease
Author(s) -
Burk Raymond F.
Publication year - 1988
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840080240
Subject(s) - cholestasis of pregnancy , pregnancy , selenium , cholestasis , glutathione peroxidase , selenium deficiency , post partum , medicine , peroxidase , endocrinology , disease , physiology , glutathione , fetus , obstetrics , gastroenterology , enzyme , oxidative stress , biology , chemistry , biochemistry , catalase , genetics , organic chemistry
Serum selenium concentrations were found to be significantly lower in women with intrahepatic cholestasis of pregnancy than in women with normal pregnancies during the last trimester of pregnancy and post partum. The activity of the seleno‐enzyme glutathione peroxidase had a significant positive correlation with selenium concentration and it was also significantly lower in women with the disease. These findings suggest that selenium deficiency and reduced glutathione peroxidase activity are associated with the aetiopathogenesis of intrahepatic cholestasis of pregnancy.