Is the magnetic resonance imaging proton spin‐lattice relaxation time a reliable noninvasive parameter of developing liver fibrosis? | Zendy

Chamuleau Robert A. F. M. | Zendy; De Nie Joris H. N. Creyghton Ineke | Zendy; Moerland Marinus A. | Zendy; Van der Lende Otto R. | Zendy; Smidt Jaap | Zendy

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Is the magnetic resonance imaging proton spin‐lattice relaxation time a reliable noninvasive parameter of developing liver fibrosis?

Author(s) -

Chamuleau Robert A. F. M.,

De Nie Joris H. N. Creyghton Ineke,

Moerland Marinus A.,

Van der Lende Otto R.,

Smidt Jaap

Publication year - 1988

Publication title -

hepatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.488

H-Index - 361

eISSN - 1527-3350

pISSN - 0270-9139

DOI - 10.1002/hep.1840080204

Subject(s) - in vivo , ccl4 , carbon tetrachloride , spin–lattice relaxation , magnetic resonance imaging , hepatic fibrosis , liver biopsy , fibrosis , nuclear magnetic resonance , medicine , liver fibrosis , proton magnetic resonance , pathology , biopsy , chemistry , endocrinology , radiology , biology , physics , microbiology and biotechnology , organic chemistry , nuclear quadrupole resonance

During the development of liver fibrosis in rats by an individual dose‐titrated CCl 4 administration, hepatic proton spin‐lattice relaxation time (T 1 ) has been measured in vivo every 2 weeks for 8 weeks. Liver content of collagen, triglycerides and water has been measured biochemically in biopsy material. After 4 weeks of CCl 4 treatment, T 1 increased signifcantly and remained at the same level, whereas liver collagen reached its maximum at 8 weeks. It is concluded that, under our experimental conditions, increased hepatic T 1 represents drug‐induced edema and that hepatic T 1 is not a reliable noninvasive parameter for developing liver fibrosis in vivo .

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