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Is the magnetic resonance imaging proton spin‐lattice relaxation time a reliable noninvasive parameter of developing liver fibrosis?
Author(s) -
Chamuleau Robert A. F. M.,
De Nie Joris H. N. Creyghton Ineke,
Moerland Marinus A.,
Van der Lende Otto R.,
Smidt Jaap
Publication year - 1988
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840080204
Subject(s) - in vivo , ccl4 , carbon tetrachloride , spin–lattice relaxation , magnetic resonance imaging , hepatic fibrosis , liver biopsy , fibrosis , nuclear magnetic resonance , medicine , liver fibrosis , proton magnetic resonance , pathology , biopsy , chemistry , endocrinology , radiology , biology , physics , microbiology and biotechnology , organic chemistry , nuclear quadrupole resonance
During the development of liver fibrosis in rats by an individual dose‐titrated CCl 4 administration, hepatic proton spin‐lattice relaxation time (T 1 ) has been measured in vivo every 2 weeks for 8 weeks. Liver content of collagen, triglycerides and water has been measured biochemically in biopsy material. After 4 weeks of CCl 4 treatment, T 1 increased signifcantly and remained at the same level, whereas liver collagen reached its maximum at 8 weeks. It is concluded that, under our experimental conditions, increased hepatic T 1 represents drug‐induced edema and that hepatic T 1 is not a reliable noninvasive parameter for developing liver fibrosis in vivo .