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Primary biliary cirrhosis and the crest syndrome: New terminology?
Author(s) -
Epstein Owen
Publication year - 1988
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840080137
Subject(s) - crest syndrome , keratoconjunctivitis sicca , primary biliary cirrhosis , medicine , dermatology , scleroderma (fungus) , sicca syndrome , gastroenterology , antibody , pathology , immunology , connective tissue disease , autoimmune disease , disease , inoculation
The syndrome of primary biliary cirrhosis and limited scleroderma (the CREST syndrome) is described in 22 patients. The syndrome is expanded to include a serologic marker—the anticentromere antibody—and keratoconjunctivitis sicca. The acronym “PACK” ( p rimary biliary cirrhosis, a nticentromere antibody, C REST syndrome, and k eratoconjunctivitis sicca) with “syndrome” is suggested to facilitate recall of the various components of this entity.