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The protective effects of prostaglandin E 1 in an experimental massive hepatic cell necrosis model
Author(s) -
Mizoguchi Yasuhiro,
Tsutsui Hiroko,
Miyajima Keiji,
Sakagami Yoshihide,
Seki Shuichi,
Kobayashi Kenzo,
Yamamoto Sukeo,
Morisawa Seiji
Publication year - 1987
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840070603
Subject(s) - cytotoxic t cell , lipopolysaccharide , prostaglandin , prostaglandin e1 , tumor necrosis factor alpha , prostaglandin e , necrosis , prostaglandin e2 , endocrinology , medicine , chemistry , pharmacology , biology , biochemistry , in vitro
When a small amount of Gram‐negative lipopolysaccharide was intravenously injected into mice which had been injected with heat‐killed Propionibacterium acnes 7 days before, massive hepatic cell necrosis was induced and most of the mice died 24 hr later. However, when prostaglandin E 1 was administered with lipopolysaccharide, remarkable improvements in the survival rate and in the histological changes of the liver were observed. In order to find out how prostaglandin E 1 suppressed the induction of massive hepatic cell necrosis in this experimental model, we studied the effects of prostaglandin E 1 on the activation of liver adherent cells, from which the cytotoxic factor is released, and on the protection of hepatocytes from the cytotoxic factor. As a result, prostaglandin E 1 not only inhibited the activation of liver adherent cells and suppressed the release of the cytotoxic factor, but it also directly affected the hepatocytes and protected them from the cytotoxic factor.