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Overnight salivary caffeine clearance: A liver function test suitable for routine use
Author(s) -
Jost Gerhard,
Wahlländer Axel,
Mandach Ursula Von,
Preisig Rudolf
Publication year - 1987
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840070221
Subject(s) - caffeine , saliva , breath test , medicine , indocyanine green , bedtime , liver function tests , liver function , gastroenterology , liver disease , ambulatory , endocrinology , chemistry , surgery , helicobacter pylori
The feasibility of measuring caffeine clearance from saliva (SCI) was assessed in ambulatory patients with liver disease and in a control group, and the results were compared with quantitative liver function tests. For this purpose, the subjects were given 280 mg caffeine p.o. in decaffeinated coffee powder between noon and 4 p.m., and caffeine concentrations were measured in saliva (using an enzyme immunoassay) before bedtime and upon arising. In the cirrhotics (n = 29), SCI was 0.58 ± S.D. 0.45 ml per min × kg, thus being reduced to approximately one‐third of drug‐free, nonsmoking controls (1.53 ± 0.46, n = 18); although patients with non‐cirrhotic liver disease showed intermediate values (0.95 ± 0.47), their reduction in SCI was significant (p < 0.001). SCI was correlated with indocyanine green fractional clearance, galactose elimination capacity and aminopyrine breath test; however, the closest relationship (R s = 0.80) was observed with the aminopyrine breath test. It is suggested that the measurement of SCI represents a noninvasive and innocuous procedure for quantifying hepatic microsomal function, and is suitable for routine use. Since a.m. saliva concentrations of caffeine are highly correlated (R s = −0.94) with SCl, further simplification of the test to a single‐point measurement appears possible.