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Ground‐glass hepatocytes: A spectrum of inclusions
Author(s) -
Gerber Michael A.,
Grases Pedro J.
Publication year - 1986
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840060640
Subject(s) - endoplasmic reticulum , haematoxylin , intracellular , cytoplasm , eosin , staining , electron microscope , hepatocyte , amorphous solid , ultrastructure , pathology , biology , chemistry , biophysics , anatomy , microbiology and biotechnology , crystallography , biochemistry , optics , medicine , physics , in vitro
A new type of ground‐glass hepatocyte is described. The appearance is due to pale, homogeneous, weakly eosinophilic inclusions filling a portion of or the entire hepatocytic cytoplasm. On haematoxylin and eosin stained sections, these cells closely resemble ground‐glass hepatocytes described in other conditions. However, they are negative on special stains for HBsAg and on PAS staining. Immunohistochemically, they reveal a selective and exclusive positivity for fibrinogen. On electron microscopy, the immunoreactive fibrinogen appears as amorphous, fluffy or granular material within dilated cisternae of the rough endoplasmic reticulum. This finding suggests intracellular storage possibly reflecting a defective intracellular transport of fibrinogen.