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Immunoglobulin a antibody against hepatitis B core antigen of polymeric and monomeric forms, as well as of IgA1 and IgA2 subclasses, in acute and chronic infection with hepatitis B virus
Author(s) -
Hikata Mikio,
Tachibana Katsumi,
Imai Mitsunobu,
Naito Shigeko,
Oinuma Akira,
Tsuda Fumio,
Miyakawa Yuzo,
Mayumi Makoto
Publication year - 1986
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840060418
Subject(s) - antibody , subclass , radioimmunoassay , antigen , immunology , hepatitis , medicine , virology , hepatitis b virus , hepatitis b , immunoglobulin m , immunoglobulin g , virus
Solid‐phase radioimmunoassays using monoclonal antibodies were used to assay antibody to hepatitis B core antigen of immunoglobulin A class in terms of polymeric and monomeric forms, as well as of IgA1 and IgA2 subclasses, in the serum of persons infected with hepatitis B virus. The level of secretory immunoglobulin A antibody was significantly higher in patients with acute hepatitis (mean ± S.E., sample per normal ratio = 29.2 ± 1.9) than that in asymptomatic carriers (2.1 ± 0.1), patients with chronic persistent hepatitis (3.5 ± 0.5), patients with chronic active hepatitis (6.9 ± 1.3) or patients with cirrhosis (5.8 ± 1.1). In acute type B hepatitis, only polymeric immunoglobulin A antibody of either IgA1 or IgA2 subclass was detected. In contrast, in chronic infection, antibody to hepatitis B core antigen of IgA2 subclass was found in the polymeric form, but antibody of IgA1 subclass was detected in both polymeric and monomeric forms.