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Multivariate analysis of prognostic factors in fulminant hepatitis B
Author(s) -
Bernuau Jacques,
Goudeau Alain,
Poynard Thierry,
Dubois Frederic,
Lesage Gerard,
Yvonnet Bernard,
Degott Claude,
Bezeaud Annie,
Rueff Bernard,
Benhamou JeanPierre
Publication year - 1986
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840060417
Subject(s) - radioimmunoassay , hbsag , medicine , fulminant hepatitis , multivariate analysis , gastroenterology , fulminant , hepatitis b , hepatitis , immunology , hepatitis b virus , virus
We assessed prognostic factors in 115 patients with serologically defined fulminant hepatitis B. The diagnosis in each case was based on the finding of IgM antibody to the hepatitis B core antigen in serum. Multivariate analysis showed that factor V level (p < 0.001), patient's age (p = 0.001), absence of detectable HBsAg by radioimmunoassay (p = 0.06) and serum α‐fetoprotein concentration (p = 0.07) were independent predictors of survival. The survival rate in the 21 patients in whom HBsAg was not detected was 47%, which was significantly higher than the survival rate of 17% observed in the 94 HBsAg‐positive patients (p = 0.006). In patients with fulminant hepatitis B, the absence of HBsAg in serum as detected by radioimmunoassay has an independent, favorable prognostic value.