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Absence of detectable serum interferon in acute and chronic viral hepatitis
Author(s) -
Pirovino Mauro,
Aguet Michel,
Huber Marcel,
Altorfer Josef,
Schmid Martin
Publication year - 1986
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840060416
Subject(s) - medicine , interferon , viral hepatitis , immunology , virology , hepatitis , viral disease , chronic hepatitis , virus
Amounts of interferon were measured in sera from 59 patients with acute viral hepatitis and 49 patients with chronic hepatitis B and compared to those from patients with nonviral liver disease or influenza, and from healthy controls. In all patients with acute and chronic viral hepatitis, no serum interferon could be detected, confirming data from earlier studies of acute viral hepatitis in which no circulating interferon was found. Our results disprove the view that the amounts of serum interferon, detected at the time of the acute clinical illness, may be a determinant of outcome.