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Hepatic hemodynamics and oxygen consumption in alcoholic fatty liver assessed by organ‐reflectance spectrophotometry and the hydrogen clearance method
Author(s) -
Kasahara Akinori,
Hayashi Norio,
Kurosawa Kazuhei,
Sasaki Yutaka,
Sato Nobuhiro,
Kamada Takenobu
Publication year - 1986
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840060116
Subject(s) - oxygen , fatty liver , hemodynamics , spectrophotometry , chemistry , medicine , chromatography , organic chemistry , disease
Hepatic blood flow and estimated hepatic oxygen consumption were studied in rats treated chronically with ethanol by organ‐reflectance spectrophotometry and the hydrogen clearance method. In the withdrawal state from ethanol, the concentration of hemoglobin in the hepatic tissue (ΔEr 569—650 ), the estimated hepatic oxygen consumption (estimated VO 2 ) and the regional liver blood flow decreased significantly in rats treated chronically with ethanol in comparison with their controls. On the other hand, there was no significant difference in the estimated oxygen saturation of the hepatic blood hemoglobin (estimated SO 2 ) between both groups. That is, an increase in oxygen extraction, which was exhibited by a decrease in the estimated SO 2 , did not occur in rats treated chronically with ethanol in spite of a decrease in blood supply. Thus, in the withdrawal state from ethanol, both oxygen delivery to the liver and oxygen utilization in the liver weredisturbed at the stage of alcoholic fatty liver.