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High density lipoprotein subpopulations in chronic liver disease
Author(s) -
Chang Linus,
Clifton Peter,
Barter Philip,
Mackin, M.D. Malcolm
Publication year - 1986
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840060109
Subject(s) - lipoprotein , medicine , high density lipoprotein , cirrhosis , endocrinology , chronic liver disease , very low density lipoprotein , low density lipoprotein , liver disease , chemistry , cholesterol
Severe liver disease may be associated with a reduction in plasma concentration of high density lipoprotein and an impairment of plasma cholesterol esterification. These changes were confirmed in two patients with severe acute on chronic alcoholic liver disease. In five additional patients with biopsy‐proven clinically compensated cirrhosis, there wasminimal reduction in concentration of plasma cholesteryl esters; there was, however a reduction of the plasma high density lipoprotein concentration to only 48 to 66% of normal. The particle size distribution of high density lipoprotein in these five patients was determined by gradient gel electrophoresis. The high density lipoprotein 2 subfraction was preserved. The high density lipoprotein 3 subfraction, however, was markedly changed with a reduction in the normal particles of radius 4.3 m and an accentuation of smaller particles of radius 3.9 m; in two patients, these smaller particles were the major high density lipoprotein subpopulation. Further investigations of this finding of a distinctive distribution of high density lipoprotein subpopulations in patient with chronic liver disease may provide new insights into high density lipoprotein metabolism.