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Improved survival following injection sclerotherapy for esophageal varices: Final analysis of a controlled trial
Author(s) -
Westaby David,
Macdougall Brian R. D.,
Williams Roger
Publication year - 1985
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840050520
Subject(s) - sclerotherapy , medicine , esophageal varices , varices , varix , surgery , gastroenterology , gastric varices , portal hypertension , cirrhosis
Long‐term follow‐up (median: 37 months; range: 19 to 68) of the 116 patients (56 sclerotherapy, 60 control group) entered into a controlled trial of endoscopic variceal sclerotherapy has shown a total of 18 deaths in the sclerotherapy group, including five from variceal bleeding compared with 32 deaths in the control group (p < 0.01), of which 25 were from variceal hemorrhage (p < 0.001). Survival as assessed by cumulative life analysis was significantly better in those treated by sclerotherapy (p < 0.001). Both the cumulative proportion of patients rebleeding and the total number of episodes of variceal hemorrhage were also significantly less in the sclerotherapy group (p < 0.01). Recurrence of varices was observed in 27 of 45 patients in whom variceal obliteration was initially observed at a median of 11 months (range: 2 to 27) later, although in only 12 of these did bleeding recur and was the cause of death in one.