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Functional properties of isolated hepatocytes from ethanol‐treated rat liver
Author(s) -
Schüller Amador,
Moscat Jorge,
Diez Emilio,
FernandezCheca Jose C.,
Gavilanes Francisco G.,
Municio Angel M.
Publication year - 1985
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840050426
Subject(s) - gluconeogenesis , ethanol , medicine , endocrinology , hormone , chemistry , basal (medicine) , hepatocyte , insulin , phosphatidylcholine , biochemistry , biology , in vitro , metabolism , phospholipid , membrane
Gluconeogenesis and palmitate incorporation into triacylglycerols and phosphatidylcholine were measured in isolated hepatocytes from control and ethanol‐treated rats. Basal gluconeogenesis and its hormonal response decreased in hepatocytes from ethanol‐treated animals; palmitate incorporation into triacylglycerols increased. In ethanol‐treated rat liver, 45 Ca 2+ uptake and methylating capacity were reduced, and the hormonal response exhibited differences in binding parameters of insulin.