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Transmission of ground squirrel hepatitis virus to homologous and heterologous hosts
Author(s) -
Trueba Daniel,
Phelan Michael,
Nelson John,
Beck Fred,
Pecha Brian S.,
Brown R. James,
Varmus Harold E.,
Ganem Don
Publication year - 1985
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840050316
Subject(s) - infectivity , ground squirrel , virology , virus , biology , heterologous , squirrel monkey , woodchuck hepatitis virus , rodent , host (biology) , titration , hepatitis b virus , chemistry , hepadnaviridae , ecology , genetics , inorganic chemistry , gene
Abstract The infectivity and host range of ground squirrel hepatitis virus (GSHV) have been further examined by animal inoculation experiments. Although carrier squirrel sera usually harbor 10 9 to 10 10 virions per ml as determined by physical measurements, titration of one such serum revealed that squirrel infectivity was lost following dilution of the sample over 10 6 ‐fold. Infectivity is markedly reduced by NP40 pretreatment of infected serum. GSHV infection cannot be readily transmitted to several related ground squirrel species, but chipmunks can be experimentally infected by GSHV virions or by cloned GSHV DNA, and the resulting infection closely resembles that seen in the normal host.