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Synthesis of heat shock proteins in rat liver after ischemia and hyperthermia
Author(s) -
Cairo Gaetano,
Bardella Lidia,
Schiaffonati Luisa,
BernelliZazzera Aldo
Publication year - 1985
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840050303
Subject(s) - hyperthermia , heat shock protein , ischemia , polysome , hsp70 , shock (circulatory) , liver cell , protein biosynthesis , cell , messenger rna , chemistry , medicine , endocrinology , biology , biochemistry , rna , gene , ribosome
Abstract Ischemia of rat liver is followed by recovery or cell death. Since heat shock proteins may be essential to cell survival under stress, we determined levels of heat shock proteins in liver after different periods of blood deprivation and correlated the results with cellular recovery. Cell‐free synthesis by poly (A+)‐mRNA and polysomes revealed 70 and 89 kd proteins which appear similar to proteins produced by the liver of rats with amphetamine‐induced hyperthermia. The 70 and 89 kd proteins increased in the liver of rats which recovered from ischemia.