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The effects of colchicine and vinblastine on the biliary excretion of carcinoembryonic antigen
Author(s) -
Thomas Peter,
O'Neil Paul F.,
Zamcheck Norman
Publication year - 1985
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840050208
Subject(s) - vinblastine , colchicine , carcinoembryonic antigen , medicine , paracellular transport , chemistry , bile duct , endocrinology , gastroenterology , pharmacology , chemotherapy , permeability (electromagnetism) , biochemistry , cancer , membrane
The biliary output of carcinoembryonic antigen (CEA) in bile fistula rats following treatment with the microtubule poisons vinblastine and colchicine increased 3‐fold over a 4‐hr period. Cytochalasin B and the inactive colchicine derivative lumicolchicine had no effect. These treatments did not effect the rate of CEA clearance from the circulation. Biliary output of low molecular weight fragments from CEA degradation was decreased in the presence of colchicine and vinblastine. Mechanical obstruction of the bile duct for 3 days followed by relief of obstruction resulted in a 3‐fold increased output of CEA into the bile. These results are consistent with a paracellular mechanism for CEA transport from blood to bile. Biliary duct obstruction and vinblastine and colchicine probably affect the permeability of junctional complexes between hepatocytes allowing CEA to penetrate more easily.