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Lack of in vivo activation of the interferon system in HBsAg‐positive chronic active hepatitis
Author(s) -
Poitrine Alain,
Chousterman Suzanne,
Chousterman Michel,
Naveau Sylvie,
Thang Ming Nguy,
Chaput JeanClaude
Publication year - 1985
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840050202
Subject(s) - hbsag , in vivo , medicine , interferon , virology , hepatology , immunology , biology , hepatitis b virus , virus , genetics
The in vivo activation state of the interferon system was biochemically evaluated in patients with HBsAg‐positive liver disease by assaying the interferon‐induced enzyme, 2′5′‐oligoadenylate synthetase, in peripheral blood mononuclear cells. All patients with chronic active hepatitis had normal levels of enzyme activity. Increased values were found in 77% of patients with acute hepatitis, 50% of those with chronic persistent hepatitis and 54% chronic healthy carriers. These results provide evidence for lack of activation of the interferon system in HBsAg‐positive chronic active hepatitis and support the hypothesis that an in vivo defective interferon response may aid in development of chronic active hepatitis.