Premium
Orthotopic Liver Transplantation in Groningen, The Netherlands (1979–1983)
Author(s) -
Krom Ruud A. F.,
Gips Chris H.,
Houthoff Hendrik J.,
Newton Douglas,
Waaij Dirk V. D.,
Beelen José,
Haagsma Elizabeth B.,
Slooff Maarten J. H.
Publication year - 1984
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840040717
Subject(s) - medicine , liver transplantation , hepatocellular carcinoma , surgery , survival rate , complication , transplantation , liver cancer , orthotopic liver transplantation , gastroenterology , milan criteria
From March, 1979 to March, 1983, 26 orthotopic liver transplantations and 1 retransplantation were performed in our center. Sixteen patients are alive, 5 beyond22 years and 1 longer than 4 years after transplantation. The actuarial 1– and 2–year survival is 60%. Factors contributing to this result are patient selection and biliary anastomosis. In cirrhotic patients, the degree of deterioration of liver function correlated with survival; in patients with hepatocellular carcinoma, extrahepatic spread of tumor was the most frequent limiting factor. Choledochocholedochostomy with a widening plasty had a low complication rate providing that the arterial blood supply was undisturbed. Until now, HLA‐matching has not contributed to the result of liver transplantation, although the effect for long‐term survival is still unknown. The high survival rate and excellent quality of life of long‐term survivors justify liver transplantation as treatment for otherwise noncurable liver diseases.