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Rat Liver Regeneration After 90% Partial Hepatectomy
Author(s) -
Gaub Johannes,
Iversen Johan
Publication year - 1984
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.1840040519
Subject(s) - liver regeneration , hepatectomy , mitotic index , glucagon , regeneration (biology) , thymidine , medicine , insulin , endocrinology , mitosis , dna synthesis , biology , chemistry , dna , surgery , biochemistry , microbiology and biotechnology , resection
In previous studies, 90% partial hepatectomy in the rat was invariably accompanied by 100% mortality within 40 hr. This paper describes a technique by which 90% of the liver mass can be removed with only 14% mortality, provided that rats have free access to glucose‐containing drinking water. Measurements of total liver DNA, [ 3 H]thymidine labeling index and mitotic index suggest rapid cell proliferation, commensurate with a powerful regenerative stimulus. In the presence of normoglycemia, peripheral insulin and glucagon concentrations were elevated to levels normally observed in the portal vein.